ncRNA name | hsa-miR-34c |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB samples, normal retinas; RB cell lines WERI-RB1, Y79, SO-RB50 and HXO-RB44; RPE cell line ARPE-19; human telomerase-immortalized RPE cell line hTERT-RPE1 |
Methods | siRNA transfection, qPCR, luciferase reporter assay, CCK-8 assay, colony formation assay, transwell assay, Western blot, xenograft |
Expression pattern | down-regulated |
Functional description | Functional experiments demonstrated that miR-34c and miR-613 could reverse the oncogenic function of DANCR in RB tumorigenesis. |
PubMed ID | 29744877 |
Year | 2018 |
Title | Long noncoding RNA DANCR aggravates retinoblastoma through miR-34c and miR-613 by targeting MMP-9. |
Drug-related ncRNA | NO |
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